Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1813374..1813991 Replicon chromosome
Accession NZ_CP126977
Organism Gallibacterium anatis strain DFSO2

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A2Y920
Locus tag QP020_RS08650 Protein ID WP_039133250.1
Coordinates 1813809..1813991 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID F4HBU2
Locus tag QP020_RS08645 Protein ID WP_013746351.1
Coordinates 1813374..1813781 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QP020_RS08630 (QP020_08630) 1810140..1810835 + 696 WP_285097754.1 hypothetical protein -
QP020_RS08635 (QP020_08635) 1811016..1811606 - 591 WP_285097755.1 uracil-DNA glycosylase family protein -
QP020_RS08640 (QP020_08640) 1811682..1812794 - 1113 WP_039087924.1 aspartate-semialdehyde dehydrogenase -
QP020_RS08645 (QP020_08645) 1813374..1813781 - 408 WP_013746351.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QP020_RS08650 (QP020_08650) 1813809..1813991 - 183 WP_039133250.1 type II toxin-antitoxin system HicA family toxin Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6830.10 Da        Isoelectric Point: 10.8973

>T283438 WP_039133250.1 NZ_CP126977:c1813991-1813809 [Gallibacterium anatis]
VDSKTLIKMLEKDGWYLVNVVGSHHQFKHPIKKGRTTVPHPKKDLQIKTVNSILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14869.04 Da        Isoelectric Point: 4.4474

>AT283438 WP_013746351.1 NZ_CP126977:c1813781-1813374 [Gallibacterium anatis]
MLYPIGIEMGDDKHAFGVIVPDVPGCFSAGDTLEEAYINAKEAIAFHIEGMLEDGEEFPLPTDIKAHMNNKEFEGFTFTF
VDVDLSHLMGKAEKINITLPALLLHKIDAFIATHPEYKSRSGFLAQLATDKLLSA

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2Y920

Antitoxin

Source ID Structure
AlphaFold DB F4HBU2

References