Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1261351..1261997 Replicon chromosome
Accession NZ_CP126977
Organism Gallibacterium anatis strain DFSO2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QP020_RS05960 Protein ID WP_285099324.1
Coordinates 1261351..1261758 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0A2Z0K5
Locus tag QP020_RS05965 Protein ID WP_021461268.1
Coordinates 1261758..1261997 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QP020_RS05940 (QP020_05940) 1256360..1256605 + 246 WP_285099322.1 hypothetical protein -
QP020_RS05945 (QP020_05945) 1256800..1257918 - 1119 WP_285099323.1 iron-sulfur cluster carrier protein ApbC -
QP020_RS05950 (QP020_05950) 1258117..1260162 + 2046 WP_285099408.1 methionine--tRNA ligase -
QP020_RS05955 (QP020_05955) 1260247..1261251 + 1005 WP_039093699.1 16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC -
QP020_RS05960 (QP020_05960) 1261351..1261758 - 408 WP_285099324.1 tRNA(fMet)-specific endonuclease VapC Toxin
QP020_RS05965 (QP020_05965) 1261758..1261997 - 240 WP_021461268.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QP020_RS05970 (QP020_05970) 1262288..1263283 + 996 WP_285099326.1 thiamine ABC transporter substrate binding subunit -
QP020_RS05975 (QP020_05975) 1263259..1264881 + 1623 WP_285099328.1 thiamine/thiamine pyrophosphate ABC transporter permease -
QP020_RS05980 (QP020_05980) 1264868..1265530 + 663 WP_039085662.1 thiamine ABC transporter ATP-binding protein -
QP020_RS05985 (QP020_05985) 1265570..1266580 + 1011 WP_210640912.1 biotin synthase BioB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15006.50 Da        Isoelectric Point: 7.2412

>T283437 WP_285099324.1 NZ_CP126977:c1261758-1261351 [Gallibacterium anatis]
MLKYMLDTNIVIFTIKNKPPHLLPLFNENQSMLCISSITLMELVYGAEKSKKTAQNLAVIESFCARLAVLDYDEAAAYHS
GQIRAELAKIGQPIGSYDAMIAGHARSLGLTVVTNNMNEFSRVEGLRVIDWSKPM

Download         Length: 408 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9043.25 Da        Isoelectric Point: 4.4013

>AT283437 WP_021461268.1 NZ_CP126977:c1261997-1261758 [Gallibacterium anatis]
MSVVTATVFMNNKSQAIRIPKAAELPNTTKSVNIIIQGDMRIITPLNNVWDSWFNDSNSVSDDFMLSREQPQMQEREEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0A2Z0K5

References