Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1208431..1208976 Replicon chromosome
Accession NZ_CP126977
Organism Gallibacterium anatis strain DFSO2

Toxin (Protein)


Gene name relE Uniprot ID F4HF99
Locus tag QP020_RS05705 Protein ID WP_013746939.1
Coordinates 1208431..1208718 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0A2ZZB6
Locus tag QP020_RS05710 Protein ID WP_039087491.1
Coordinates 1208728..1208976 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QP020_RS05675 (QP020_05675) 1203707..1204633 + 927 WP_285099268.1 phosphoserine phosphatase -
QP020_RS05680 (QP020_05680) 1204646..1205137 + 492 WP_039087484.1 YajQ family cyclic di-GMP-binding protein -
QP020_RS05685 (QP020_05685) 1205159..1205326 + 168 WP_013746943.1 DUF5363 family protein -
QP020_RS05690 (QP020_05690) 1205411..1207426 + 2016 WP_285099269.1 NAD-dependent DNA ligase LigA -
QP020_RS05695 (QP020_05695) 1207628..1207894 + 267 WP_039087486.1 antitoxin MazE -
QP020_RS05700 (QP020_05700) 1207894..1208247 + 354 WP_285099273.1 type II toxin-antitoxin system PemK/MazF family toxin -
QP020_RS05705 (QP020_05705) 1208431..1208718 - 288 WP_013746939.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QP020_RS05710 (QP020_05710) 1208728..1208976 - 249 WP_039087491.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QP020_RS05715 (QP020_05715) 1209093..1210145 - 1053 WP_285099276.1 porin -
QP020_RS05720 (QP020_05720) 1210910..1211971 + 1062 WP_285099277.1 porin -
QP020_RS05725 (QP020_05725) 1212285..1213367 - 1083 WP_285099279.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-73)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11026.94 Da        Isoelectric Point: 10.4262

>T283436 WP_013746939.1 NZ_CP126977:c1208718-1208431 [Gallibacterium anatis]
MAYAIKVHSDFVAELNKLDSTIKNQLRKKLEKVVHNPHIPKNRLSGELHNCYKIKLRKAGVRLVYQVNDDEIYILLLTVG
KREAKQVYNTALNRV

Download         Length: 288 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9345.69 Da        Isoelectric Point: 4.4230

>AT283436 WP_039087491.1 NZ_CP126977:c1208976-1208728 [Gallibacterium anatis]
MANLNIRIDDTIKQRAFLAFDNLGINPSEAIRTFLTYVADTGRMPIKQIIVSDEDAELYEVVKKRLNEPEKITATTLDEL
FS

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F4HF99

Antitoxin

Source ID Structure
AlphaFold DB A0A0A2ZZB6

References