Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH
Location 2068956..2069634 Replicon chromosome
Accession NZ_CP126975
Organism Gallibacterium anatis strain BJF12

Toxin (Protein)


Gene name relE Uniprot ID A0A0A3AQ60
Locus tag QP018_RS09865 Protein ID WP_039139159.1
Coordinates 2069251..2069634 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QP018_RS09860 Protein ID WP_013746372.1
Coordinates 2068956..2069258 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QP018_RS09835 (QP018_09835) 2064277..2064996 + 720 WP_210641021.1 DUF969 domain-containing protein -
QP018_RS09840 (QP018_09840) 2064996..2065979 + 984 WP_285090755.1 DUF979 domain-containing protein -
QP018_RS09845 (QP018_09845) 2065989..2066981 + 993 WP_285090756.1 DUF2891 domain-containing protein -
QP018_RS09850 (QP018_09850) 2067392..2068108 + 717 WP_031205117.1 amino acid ABC transporter permease -
QP018_RS09855 (QP018_09855) 2068111..2068854 + 744 WP_285090786.1 amino acid ABC transporter ATP-binding protein -
QP018_RS09860 (QP018_09860) 2068956..2069258 - 303 WP_013746372.1 DNA-binding transcriptional regulator Antitoxin
QP018_RS09865 (QP018_09865) 2069251..2069634 - 384 WP_039139159.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QP018_RS09870 (QP018_09870) 2069916..2070212 + 297 WP_018346511.1 HigA family addiction module antitoxin -
QP018_RS09875 (QP018_09875) 2070243..2070830 - 588 WP_210641902.1 Fic family protein -
QP018_RS09880 (QP018_09880) 2070799..2070990 - 192 WP_013746378.1 antitoxin VbhA family protein -
QP018_RS09885 (QP018_09885) 2071756..2073135 - 1380 WP_285090757.1 cysteine--tRNA ligase -
QP018_RS09890 (QP018_09890) 2073274..2073786 + 513 WP_013746381.1 peptidylprolyl isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-120)

Antitoxin

Cro/C1-type helix-turn-helix domain

(45-88)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14241.26 Da        Isoelectric Point: 8.9256

>T283434 WP_039139159.1 NZ_CP126975:c2069634-2069251 [Gallibacterium anatis]
MRIFKTKAFNKFALKNGIPDSELINAITRVEQGLIDADLGGNIIKQRIARKGQGRSGGFRSFIFYCIQNNSYFVAGISKN
DRENISSQELAALKALAREYTRLTAKQIEAQIENGLFIEILPEAEDE

Download         Length: 384 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11270.16 Da        Isoelectric Point: 7.3581

>AT283434 WP_013746372.1 NZ_CP126975:c2069258-2068956 [Gallibacterium anatis]
MSELLAMIHENAADLHKAGIINKKTMKEFDQLCLTPVVTYTPDEIRAIREKEQVSQAVFAHYLNVSKNMISEWERGVKKP
SGAALKLLNLVQHNGIEILV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A3AQ60

Antitoxin

Source ID Structure

References