Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2033280..2033897 Replicon chromosome
Accession NZ_CP126975
Organism Gallibacterium anatis strain BJF12

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A2Y920
Locus tag QP018_RS09770 Protein ID WP_039133250.1
Coordinates 2033715..2033897 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID F4HBU2
Locus tag QP018_RS09765 Protein ID WP_013746351.1
Coordinates 2033280..2033687 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QP018_RS09740 (QP018_09740) 2028850..2029524 - 675 WP_285090783.1 hypothetical protein -
QP018_RS09745 (QP018_09745) 2029719..2030138 + 420 WP_021461944.1 helix-turn-helix domain-containing protein -
QP018_RS09750 (QP018_09750) 2030622..2030804 + 183 WP_013746348.1 glycine zipper 2TM domain-containing protein -
QP018_RS09755 (QP018_09755) 2030920..2031510 - 591 WP_285090749.1 uracil-DNA glycosylase family protein -
QP018_RS09760 (QP018_09760) 2031588..2032700 - 1113 WP_285090750.1 aspartate-semialdehyde dehydrogenase -
QP018_RS09765 (QP018_09765) 2033280..2033687 - 408 WP_013746351.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QP018_RS09770 (QP018_09770) 2033715..2033897 - 183 WP_039133250.1 type II toxin-antitoxin system HicA family toxin Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6830.10 Da        Isoelectric Point: 10.8973

>T283433 WP_039133250.1 NZ_CP126975:c2033897-2033715 [Gallibacterium anatis]
VDSKTLIKMLEKDGWYLVNVVGSHHQFKHPIKKGRTTVPHPKKDLQIKTVNSILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14869.04 Da        Isoelectric Point: 4.4474

>AT283433 WP_013746351.1 NZ_CP126975:c2033687-2033280 [Gallibacterium anatis]
MLYPIGIEMGDDKHAFGVIVPDVPGCFSAGDTLEEAYINAKEAIAFHIEGMLEDGEEFPLPTDIKAHMNNKEFEGFTFTF
VDVDLSHLMGKAEKINITLPALLLHKIDAFIATHPEYKSRSGFLAQLATDKLLSA

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2Y920

Antitoxin

Source ID Structure
AlphaFold DB F4HBU2

References