Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5183166..5183791 Replicon chromosome
Accession NZ_CP126974
Organism Klebsiella pneumoniae subsp. pneumoniae strain 111-2

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag QPX97_RS24980 Protein ID WP_002882817.1
Coordinates 5183166..5183549 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag QPX97_RS24985 Protein ID WP_004150355.1
Coordinates 5183549..5183791 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPX97_RS24965 (QPX97_24965) 5180532..5181434 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
QPX97_RS24970 (QPX97_24970) 5181431..5182066 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
QPX97_RS24975 (QPX97_24975) 5182063..5182992 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
QPX97_RS24980 (QPX97_24980) 5183166..5183549 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
QPX97_RS24985 (QPX97_24985) 5183549..5183791 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
QPX97_RS24990 (QPX97_24990) 5183996..5184913 + 918 WP_012737090.1 alpha/beta hydrolase -
QPX97_RS24995 (QPX97_24995) 5184927..5185868 - 942 WP_012543287.1 fatty acid biosynthesis protein FabY -
QPX97_RS25000 (QPX97_25000) 5185913..5186350 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
QPX97_RS25005 (QPX97_25005) 5186347..5187207 - 861 WP_004146232.1 virulence factor BrkB family protein -
QPX97_RS25010 (QPX97_25010) 5187201..5187800 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T283429 WP_002882817.1 NZ_CP126974:c5183549-5183166 [Klebsiella pneumoniae subsp. pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT283429 WP_004150355.1 NZ_CP126974:c5183791-5183549 [Klebsiella pneumoniae subsp. pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References