Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4600563..4601373 Replicon chromosome
Accession NZ_CP126974
Organism Klebsiella pneumoniae subsp. pneumoniae strain 111-2

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag QPX97_RS22250 Protein ID WP_004178461.1
Coordinates 4600563..4601096 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag QPX97_RS22255 Protein ID WP_002887278.1
Coordinates 4601107..4601373 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPX97_RS22245 (QPX97_22245) 4599394..4600515 + 1122 WP_064153030.1 cupin domain-containing protein -
QPX97_RS22250 (QPX97_22250) 4600563..4601096 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
QPX97_RS22255 (QPX97_22255) 4601107..4601373 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
QPX97_RS22260 (QPX97_22260) 4601476..4602909 - 1434 WP_009484674.1 Cu(+)/Ag(+) sensor histidine kinase -
QPX97_RS22265 (QPX97_22265) 4602899..4603582 - 684 WP_004214143.1 copper response regulator transcription factor CusR -
QPX97_RS22270 (QPX97_22270) 4603755..4605140 + 1386 WP_064153031.1 efflux transporter outer membrane subunit -
QPX97_RS22275 (QPX97_22275) 4605158..4605502 + 345 WP_048266266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T283426 WP_004178461.1 NZ_CP126974:c4601096-4600563 [Klebsiella pneumoniae subsp. pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT283426 WP_002887278.1 NZ_CP126974:c4601373-4601107 [Klebsiella pneumoniae subsp. pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References