Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2604018..2605606 Replicon chromosome
Accession NZ_CP126974
Organism Klebsiella pneumoniae subsp. pneumoniae strain 111-2

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QPX97_RS12695 Protein ID WP_130974847.1
Coordinates 2604018..2605340 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QPX97_RS12700 Protein ID WP_004176198.1
Coordinates 2605340..2605606 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPX97_RS12680 (QPX97_12680) 2599074..2601575 + 2502 WP_064153112.1 fimbria/pilus outer membrane usher protein -
QPX97_RS12685 (QPX97_12685) 2601563..2602567 + 1005 WP_004176196.1 fimbrial protein -
QPX97_RS12690 (QPX97_12690) 2602709..2604001 + 1293 WP_032414911.1 glycoside hydrolase family 10 protein -
QPX97_RS12695 (QPX97_12695) 2604018..2605340 - 1323 WP_130974847.1 type II toxin-antitoxin system HipA family toxin Toxin
QPX97_RS12700 (QPX97_12700) 2605340..2605606 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QPX97_RS12705 (QPX97_12705) 2605993..2606319 - 327 WP_004224757.1 hydroxyisourate hydrolase -
QPX97_RS12710 (QPX97_12710) 2606316..2606816 - 501 WP_130974846.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QPX97_RS12715 (QPX97_12715) 2606794..2608173 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
QPX97_RS12720 (QPX97_12720) 2608519..2609673 + 1155 WP_130974845.1 FAD-dependent urate hydroxylase HpxO -
QPX97_RS12725 (QPX97_12725) 2609654..2610577 - 924 WP_004184020.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49115.40 Da        Isoelectric Point: 7.5357

>T283424 WP_130974847.1 NZ_CP126974:c2605340-2604018 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATATTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT283424 WP_004176198.1 NZ_CP126974:c2605606-2605340 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References