Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 774812..775469 Replicon chromosome
Accession NZ_CP126974
Organism Klebsiella pneumoniae subsp. pneumoniae strain 111-2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag QPX97_RS03840 Protein ID WP_002916310.1
Coordinates 775059..775469 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QPX97_RS03835 Protein ID WP_002916312.1
Coordinates 774812..775078 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPX97_RS03810 (QPX97_03810) 769968..771401 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
QPX97_RS03815 (QPX97_03815) 771520..772248 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
QPX97_RS03820 (QPX97_03820) 772298..772609 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
QPX97_RS03825 (QPX97_03825) 772773..773432 + 660 WP_002916317.1 hemolysin III family protein -
QPX97_RS03830 (QPX97_03830) 773583..774566 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
QPX97_RS03835 (QPX97_03835) 774812..775078 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QPX97_RS03840 (QPX97_03840) 775059..775469 + 411 WP_002916310.1 protein YgfX Toxin
QPX97_RS03845 (QPX97_03845) 775476..775997 - 522 WP_002916308.1 flavodoxin FldB -
QPX97_RS03850 (QPX97_03850) 776098..776994 + 897 WP_064153067.1 site-specific tyrosine recombinase XerD -
QPX97_RS03855 (QPX97_03855) 777017..777730 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QPX97_RS03860 (QPX97_03860) 777736..779469 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T283419 WP_002916310.1 NZ_CP126974:775059-775469 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT283419 WP_002916312.1 NZ_CP126974:774812-775078 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References