Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 194386..195125 Replicon chromosome
Accession NZ_CP126974
Organism Klebsiella pneumoniae subsp. pneumoniae strain 111-2

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag QPX97_RS00955 Protein ID WP_021312536.1
Coordinates 194640..195125 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag QPX97_RS00950 Protein ID WP_003026799.1
Coordinates 194386..194652 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPX97_RS00935 (QPX97_00935) 189889..191958 + 2070 WP_002922127.1 glycine--tRNA ligase subunit beta -
QPX97_RS00940 (QPX97_00940) 192255..193624 + 1370 WP_087830479.1 IS3 family transposase -
QPX97_RS00945 (QPX97_00945) 193825..194253 + 429 WP_004901287.1 GFA family protein -
QPX97_RS00950 (QPX97_00950) 194386..194652 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
QPX97_RS00955 (QPX97_00955) 194640..195125 + 486 WP_021312536.1 GNAT family N-acetyltransferase Toxin
QPX97_RS00960 (QPX97_00960) 195469..195621 + 153 WP_002922102.1 type I toxin-antitoxin system toxin HokA -
QPX97_RS00965 (QPX97_00965) 195923..197542 + 1620 WP_032415799.1 ABC-F family ATP-binding cassette domain-containing protein -
QPX97_RS00970 (QPX97_00970) 197641..197853 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
QPX97_RS00975 (QPX97_00975) 198106..198396 - 291 WP_002921931.1 HTH-type transcriptional regulator -
QPX97_RS00980 (QPX97_00980) 198642..199997 - 1356 WP_032415797.1 aromatic acid/H+ symport family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 192899..193624 725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17608.39 Da        Isoelectric Point: 10.3370

>T283416 WP_021312536.1 NZ_CP126974:194640-195125 [Klebsiella pneumoniae subsp. pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT283416 WP_003026799.1 NZ_CP126974:194386-194652 [Klebsiella pneumoniae subsp. pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References