Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 358648..359549 | Replicon | chromosome |
| Accession | NZ_CP126970 | ||
| Organism | Corynebacterium sp. LM112 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | QP029_RS01830 | Protein ID | WP_284875188.1 |
| Coordinates | 359094..359549 (+) | Length | 152 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | - |
| Locus tag | QP029_RS01825 | Protein ID | WP_284875187.1 |
| Coordinates | 358648..359097 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QP029_RS01800 (QP029_01800) | 354033..355103 | + | 1071 | WP_284875182.1 | histidine kinase | - |
| QP029_RS01805 (QP029_01805) | 355100..355771 | + | 672 | WP_284875183.1 | response regulator transcription factor | - |
| QP029_RS01810 (QP029_01810) | 355852..356760 | + | 909 | WP_284875184.1 | ABC transporter ATP-binding protein | - |
| QP029_RS01815 (QP029_01815) | 356757..357515 | + | 759 | WP_284875185.1 | ABC transporter permease | - |
| QP029_RS01820 (QP029_01820) | 357569..358264 | + | 696 | WP_284875186.1 | ABC transporter permease | - |
| QP029_RS01825 (QP029_01825) | 358648..359097 | + | 450 | WP_284875187.1 | helix-turn-helix domain-containing protein | Antitoxin |
| QP029_RS01830 (QP029_01830) | 359094..359549 | + | 456 | WP_284875188.1 | PIN domain-containing protein | Toxin |
| QP029_RS01835 (QP029_01835) | 359708..361270 | + | 1563 | WP_284875189.1 | IS21 family transposase | - |
| QP029_RS01840 (QP029_01840) | 361267..362013 | + | 747 | WP_284874266.1 | ATP-binding protein | - |
| QP029_RS01845 (QP029_01845) | 362419..363120 | - | 702 | WP_284875190.1 | DUF981 family protein | - |
| QP029_RS01850 (QP029_01850) | 363134..363382 | - | 249 | WP_284875191.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 333221..370709 | 37488 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 152 a.a. Molecular weight: 17157.41 Da Isoelectric Point: 4.2532
>T283413 WP_284875188.1 NZ_CP126970:359094-359549 [Corynebacterium sp. LM112]
VSGFTVIYDANVLYPTMLRDILIRLAGTGIYQARWTEDILDEVFRNLQANRSDLDPSKLRRTRELMCRAVDDCLVTGYED
LIESLSLPDPDDRHVLAAAIRCGAQVIVTENARDFPQDVMDRYGIEIQGADEFLCDQIDLFGTRVHQAVTY
VSGFTVIYDANVLYPTMLRDILIRLAGTGIYQARWTEDILDEVFRNLQANRSDLDPSKLRRTRELMCRAVDDCLVTGYED
LIESLSLPDPDDRHVLAAAIRCGAQVIVTENARDFPQDVMDRYGIEIQGADEFLCDQIDLFGTRVHQAVTY
Download Length: 456 bp
Antitoxin
Download Length: 150 a.a. Molecular weight: 16367.56 Da Isoelectric Point: 5.9917
>AT283413 WP_284875187.1 NZ_CP126970:358648-359097 [Corynebacterium sp. LM112]
MSHLQDNELASTAATAREALQKINRVLSDTSTNKDVKVVVENSDDVILLPREVATVLREILVNSAAGRSVGVIPMRAELT
TQQAANLLNVSRPHVIKLMDDGILPGHKVGTHRRIYAADVQAYKHQRDIDTRTAADDLTALTEEMGLYE
MSHLQDNELASTAATAREALQKINRVLSDTSTNKDVKVVVENSDDVILLPREVATVLREILVNSAAGRSVGVIPMRAELT
TQQAANLLNVSRPHVIKLMDDGILPGHKVGTHRRIYAADVQAYKHQRDIDTRTAADDLTALTEEMGLYE
Download Length: 450 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|