Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 1168584..1169158 Replicon chromosome
Accession NZ_CP126962
Organism Globicatella sanguinis strain UMB0514

Toxin (Protein)


Gene name mazF Uniprot ID A0A2I1PHX1
Locus tag CYJ72_RS05055 Protein ID WP_066124768.1
Coordinates 1168584..1168928 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2I1PHY3
Locus tag CYJ72_RS05060 Protein ID WP_066124770.1
Coordinates 1168928..1169158 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CYJ72_RS05040 (CYJ72_005040) 1164764..1165984 - 1221 WP_284630818.1 ATP-binding protein -
CYJ72_RS05045 (CYJ72_005045) 1166140..1167231 - 1092 WP_066124764.1 alpha/beta fold hydrolase -
CYJ72_RS05050 (CYJ72_005050) 1167317..1168168 - 852 WP_284630819.1 hypothetical protein -
CYJ72_RS05055 (CYJ72_005055) 1168584..1168928 - 345 WP_066124768.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CYJ72_RS05060 (CYJ72_005060) 1168928..1169158 - 231 WP_066124770.1 hypothetical protein Antitoxin
CYJ72_RS05065 (CYJ72_005065) 1169536..1170405 - 870 WP_066124772.1 carbohydrate ABC transporter permease -
CYJ72_RS05070 (CYJ72_005070) 1170405..1171331 - 927 WP_066124774.1 sugar ABC transporter permease -
CYJ72_RS05075 (CYJ72_005075) 1171554..1172837 - 1284 WP_066124777.1 ABC transporter substrate-binding protein -
CYJ72_RS05080 (CYJ72_005080) 1173255..1173719 + 465 WP_284630820.1 hypothetical protein -
CYJ72_RS05085 (CYJ72_005085) 1173918..1174109 - 192 WP_101813291.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13224.30 Da        Isoelectric Point: 9.4828

>T283407 WP_066124768.1 NZ_CP126962:c1168928-1168584 [Globicatella sanguinis]
MLEVNSYVPSKGDIVWFDFDPSAGKEIQKRRPALVVSRHDFNRTTGFAIVCPITTTQLNYPTRVQLPHMIKTKGQIVIPQ
LKSLDFNSRQVEFIEKLPEGYIQRVDQIIQYIFN

Download         Length: 345 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8438.45 Da        Isoelectric Point: 3.7468

>AT283407 WP_066124770.1 NZ_CP126962:c1169158-1168928 [Globicatella sanguinis]
MLTTKTRTQGNSIVVTLPVAENIELQSQKEYFVTYLDDGSIILTPKVEDPFLVAEDGAYYEAEVLEGIPTSGNEVW

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I1PHX1

Antitoxin

Source ID Structure
AlphaFold DB A0A2I1PHY3

References