Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/Txe-RelB
Location 1930191..1930690 Replicon chromosome
Accession NZ_CP126958
Organism Aerococcus sp. UMB0080

Toxin (Protein)


Gene name relB Uniprot ID A0A2I1L6Q3
Locus tag CJ190_RS08780 Protein ID WP_070598209.1
Coordinates 1930436..1930690 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2I1L6Q6
Locus tag CJ190_RS08775 Protein ID WP_070598210.1
Coordinates 1930191..1930436 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJ190_RS08755 (CJ190_008755) 1925938..1927080 + 1143 WP_070598214.1 DUF6287 domain-containing protein -
CJ190_RS08760 (CJ190_008760) 1927252..1927899 + 648 WP_070598213.1 hypothetical protein -
CJ190_RS08765 (CJ190_008765) 1928543..1928977 - 435 WP_070598212.1 OsmC family protein -
CJ190_RS08770 (CJ190_008770) 1929298..1930035 + 738 WP_070598211.1 cyclase family protein -
CJ190_RS08775 (CJ190_008775) 1930191..1930436 + 246 WP_070598210.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CJ190_RS08780 (CJ190_008780) 1930436..1930690 + 255 WP_070598209.1 Txe/YoeB family addiction module toxin Toxin
CJ190_RS08785 (CJ190_008785) 1930911..1932164 - 1254 WP_070598208.1 CoA transferase -
CJ190_RS08790 (CJ190_008790) 1932332..1933279 - 948 WP_070598207.1 nitronate monooxygenase family protein -
CJ190_RS08795 (CJ190_008795) 1933337..1934122 - 786 WP_070598206.1 enoyl-CoA hydratase/isomerase family protein -
CJ190_RS08800 (CJ190_008800) 1934356..1935309 + 954 WP_070598205.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(A) - 1803030..1940282 137252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10217.88 Da        Isoelectric Point: 10.1954

>T283405 WP_070598209.1 NZ_CP126958:1930436-1930690 [Aerococcus sp. UMB0080]
MEVHWSKRAVIERDYWKAHDPKTYNKLYKLLRAIKEDPYQGLGKPEPLKYDLTGYWSRRLSRQVRLVYRIKASAIEVLSC
KYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9548.43 Da        Isoelectric Point: 3.8488

>AT283405 WP_070598210.1 NZ_CP126958:1930191-1930436 [Aerococcus sp. UMB0080]
MEITNYSDFRQNMKKYMDVINEDSVEYTVTSQNGNDVVVMSKSDFDSLMETYHLLSSRANRENLYQAMEELDQGDYEVEE
I

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I1L6Q3

Antitoxin

Source ID Structure
AlphaFold DB A0A2I1L6Q6

References