Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1221271..1221842 Replicon chromosome
Accession NZ_CP126958
Organism Aerococcus sp. UMB0080

Toxin (Protein)


Gene name mazF Uniprot ID A0A178HCX2
Locus tag CJ190_RS05530 Protein ID WP_064293476.1
Coordinates 1221510..1221842 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A178HDW3
Locus tag CJ190_RS05525 Protein ID WP_064293475.1
Coordinates 1221271..1221516 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJ190_RS05505 (CJ190_005505) 1216744..1216956 - 213 WP_064293066.1 hypothetical protein -
CJ190_RS05510 (CJ190_005510) 1217382..1218329 - 948 WP_064293064.1 HEPN domain-containing protein -
CJ190_RS05515 (CJ190_005515) 1218552..1219211 - 660 WP_101562114.1 hypothetical protein -
CJ190_RS05520 (CJ190_005520) 1219330..1220400 + 1071 WP_082888722.1 IS30 family transposase -
CJ190_RS05525 (CJ190_005525) 1221271..1221516 + 246 WP_064293475.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CJ190_RS05530 (CJ190_005530) 1221510..1221842 + 333 WP_064293476.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CJ190_RS05535 (CJ190_005535) 1221966..1223132 - 1167 WP_070598430.1 nucleotide sugar dehydrogenase -
CJ190_RS05540 (CJ190_005540) 1223197..1224045 - 849 WP_143739149.1 hypothetical protein -
CJ190_RS05545 (CJ190_005545) 1224168..1225001 - 834 WP_083307120.1 RNA-directed DNA polymerase -
CJ190_RS05550 (CJ190_005550) 1225098..1226336 - 1239 WP_070598428.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - ugd / cps4J 1216170..1235922 19752


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-107)

Antitoxin

Antitoxin PemI-like

(1-81)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12768.93 Da        Isoelectric Point: 9.5175

>T283402 WP_064293476.1 NZ_CP126958:1221510-1221842 [Aerococcus sp. UMB0080]
MVKVKQGSIIKINLDPKQGHEQKGYRPYICLSHGIVTKYSNIAIFAPISHTKRKYPFYVELEQTKTTGKVLLDQLVTIDF
NARDYKYIEQVPDDILIDLLARVKVLFEKE

Download         Length: 333 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9370.68 Da        Isoelectric Point: 4.6017

>AT283402 WP_064293475.1 NZ_CP126958:1221271-1221516 [Aerococcus sp. UMB0080]
MPLTINKWGNSSAIRLPKQLLEELNLSQGDKLDYQVKDGQLIIKKITEVPELTVKDLFENYDGDPVNEKPQLFEQKGNEK
W

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A178HCX2

Antitoxin

Source ID Structure
AlphaFold DB A0A178HDW3

References