Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4981435..4982360 Replicon chromosome
Accession NZ_CP126955
Organism Escherichia coli O78:H4 strain APEC E123

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag QQA21_RS24380 Protein ID WP_014640052.1
Coordinates 4981974..4982360 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag QQA21_RS24375 Protein ID WP_001339382.1
Coordinates 4981435..4981944 (+) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA21_RS24345 (4977110) 4977110..4978435 + 1326 WP_001301116.1 MATE family efflux transporter DinF -
QQA21_RS24350 (4978551) 4978551..4978760 + 210 WP_001030593.1 CsbD family protein -
QQA21_RS24355 (4978802) 4978802..4979317 - 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
QQA21_RS24360 (4979635) 4979635..4979916 + 282 Protein_4753 DUF2713 domain-containing protein -
QQA21_RS24365 (4979944) 4979944..4980651 + 708 WP_015364382.1 DUF2713 family protein -
QQA21_RS24370 (4981014) 4981014..4981118 + 105 Protein_4755 tRNA-dihydrouridine synthase -
QQA21_RS24375 (4981435) 4981435..4981944 + 510 WP_001339382.1 Panacea domain-containing protein Antitoxin
QQA21_RS24380 (4981974) 4981974..4982360 + 387 WP_014640052.1 hypothetical protein Toxin
QQA21_RS24385 (4982400) 4982400..4982573 + 174 WP_000390072.1 hypothetical protein -
QQA21_RS24390 (4982621) 4982621..4982902 - 282 WP_001093917.1 pyocin activator PrtN family protein -
QQA21_RS24395 (4982939) 4982939..4983511 - 573 WP_001061348.1 3'-5' exonuclease -
QQA21_RS24400 (4983511) 4983511..4984320 - 810 WP_000206745.1 hypothetical protein -
QQA21_RS24405 (4984320) 4984320..4984682 - 363 WP_001242704.1 hypothetical protein -
QQA21_RS24410 (4984673) 4984673..4985209 - 537 WP_000008210.1 5'-deoxynucleotidase -
QQA21_RS24415 (4985337) 4985337..4986161 - 825 WP_021546497.1 DUF2303 family protein -
QQA21_RS24420 (4986227) 4986227..4986589 - 363 WP_000135680.1 protein YfdP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4976429..4998500 22071


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(6-116)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T283394 WP_014640052.1 NZ_CP126955:4981974-4982360 [Escherichia coli O78:H4]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 19576.29 Da        Isoelectric Point: 5.3338

>AT283394 WP_001339382.1 NZ_CP126955:4981435-4981944 [Escherichia coli O78:H4]
MAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHNVSLRSDPREMDAD
EVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Download         Length: 510 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References