Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3616759..3617413 Replicon chromosome
Accession NZ_CP126955
Organism Escherichia coli O78:H4 strain APEC E123

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag QQA21_RS17830 Protein ID WP_000244777.1
Coordinates 3616759..3617166 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QQA21_RS17835 Protein ID WP_000354046.1
Coordinates 3617147..3617413 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA21_RS17810 (3612716) 3612716..3614449 - 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -
QQA21_RS17815 (3614455) 3614455..3615165 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QQA21_RS17820 (3615190) 3615190..3616086 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QQA21_RS17825 (3616198) 3616198..3616719 + 522 WP_001055874.1 flavodoxin FldB -
QQA21_RS17830 (3616759) 3616759..3617166 - 408 WP_000244777.1 protein YgfX Toxin
QQA21_RS17835 (3617147) 3617147..3617413 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QQA21_RS17840 (3617656) 3617656..3618636 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
QQA21_RS17845 (3618713) 3618713..3619372 - 660 WP_000250274.1 hemolysin III family protein -
QQA21_RS17850 (3619536) 3619536..3619847 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
QQA21_RS17855 (3619892) 3619892..3621325 + 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
QQA21_RS17860 (3621382) 3621382..3622125 - 744 WP_000951948.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T283388 WP_000244777.1 NZ_CP126955:c3617166-3616759 [Escherichia coli O78:H4]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT283388 WP_000354046.1 NZ_CP126955:c3617413-3617147 [Escherichia coli O78:H4]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References