Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 984448..985066 Replicon chromosome
Accession NZ_CP126955
Organism Escherichia coli O78:H4 strain APEC E123

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QQA21_RS04950 Protein ID WP_001291435.1
Coordinates 984448..984666 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QQA21_RS04955 Protein ID WP_000344800.1
Coordinates 984692..985066 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA21_RS04915 (979737) 979737..980309 + 573 WP_000779831.1 YbaY family lipoprotein -
QQA21_RS04920 (980340) 980340..980651 - 312 WP_000409911.1 MGMT family protein -
QQA21_RS04930 (981030) 981030..981383 + 354 Protein_968 DUF1428 family protein -
QQA21_RS04935 (981425) 981425..982975 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QQA21_RS04940 (983139) 983139..983609 - 471 WP_000136192.1 YlaC family protein -
QQA21_RS04945 (983725) 983725..984276 - 552 WP_000102568.1 maltose O-acetyltransferase -
QQA21_RS04950 (984448) 984448..984666 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QQA21_RS04955 (984692) 984692..985066 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QQA21_RS04960 (985612) 985612..988761 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QQA21_RS04965 (988784) 988784..989977 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T283377 WP_001291435.1 NZ_CP126955:c984666-984448 [Escherichia coli O78:H4]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT283377 WP_000344800.1 NZ_CP126955:c985066-984692 [Escherichia coli O78:H4]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References