Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 111094..111591 Replicon chromosome
Accession NZ_CP126955
Organism Escherichia coli O78:H4 strain APEC E123

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QQA21_RS00565 Protein ID WP_001173343.1
Coordinates 111418..111591 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID J7RC38
Locus tag QQA21_RS00560 Protein ID WP_001425728.1
Coordinates 111094..111390 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA21_RS00540 (107825) 107825..108544 - 720 WP_000611288.1 two-component system response regulator DcuR -
QQA21_RS00545 (108541) 108541..110172 - 1632 WP_001216487.1 sensor histidine kinase -
QQA21_RS00550 (110353) 110353..110583 + 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
QQA21_RS00555 (110595) 110595..110867 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
QQA21_RS00560 (111094) 111094..111390 + 297 WP_001425728.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QQA21_RS00565 (111418) 111418..111591 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QQA21_RS00570 (111710) 111710..113227 - 1518 WP_001295074.1 lysine--tRNA ligase -
QQA21_RS00575 (113464) 113464..114921 - 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T283374 WP_001173343.1 NZ_CP126955:111418-111591 [Escherichia coli O78:H4]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11466.99 Da        Isoelectric Point: 4.2544

>AT283374 WP_001425728.1 NZ_CP126955:111094-111390 [Escherichia coli O78:H4]
MEGKNKFNTYVVSFNYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB J7RC38

References