Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 109854..110401 Replicon plasmid pEND_Eco 12049-2
Accession NZ_CP126954
Organism Escherichia coli O78:H4 strain APEC E12049

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag QQA22_RS26580 Protein ID WP_001384452.1
Coordinates 110123..110401 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag QQA22_RS26575 Protein ID WP_000079941.1
Coordinates 109854..110123 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA22_RS26550 (105498) 105498..106031 - 534 WP_001303319.1 transcription termination/antitermination NusG family protein -
QQA22_RS26555 (106473) 106473..106760 - 288 WP_000074849.1 conjugal transfer protein TraA -
QQA22_RS26560 (106678) 106678..106908 - 231 WP_228772074.1 ash family protein -
QQA22_RS26565 (107914) 107914..108945 + 1032 WP_000907873.1 plasmid replication initiator RepA -
QQA22_RS26570 (109641) 109641..109799 + 159 WP_000841008.1 hypothetical protein -
QQA22_RS26575 (109854) 109854..110123 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QQA22_RS26580 (110123) 110123..110401 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
QQA22_RS26585 (110441) 110441..111289 + 849 WP_001057996.1 3'-5' exonuclease -
QQA22_RS26590 (111526) 111526..111651 - 126 Protein_122 MerR family transcriptional regulator -
QQA22_RS26595 (111646) 111646..113256 + 1611 Protein_123 DDE-type integrase/transposase/recombinase -
QQA22_RS26600 (113259) 113259..114119 + 861 WP_000344784.1 TniB family NTP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul1 / qacE / aac(3)-VIa / ant(3'')-Ia - 1..114229 114229


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T283373 WP_001384452.1 NZ_CP126954:110123-110401 [Escherichia coli O78:H4]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT283373 WP_000079941.1 NZ_CP126954:109854-110123 [Escherichia coli O78:H4]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References