Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4673768..4674265 Replicon chromosome
Accession NZ_CP126952
Organism Escherichia coli O78:H4 strain APEC E12049

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QQA22_RS22880 Protein ID WP_001173343.1
Coordinates 4673768..4673941 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID A0A1V2FLJ5
Locus tag QQA22_RS22885 Protein ID WP_001317561.1
Coordinates 4673969..4674265 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA22_RS22870 (4670438) 4670438..4671895 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
QQA22_RS22875 (4672132) 4672132..4673649 + 1518 WP_000003805.1 lysine--tRNA ligase -
QQA22_RS22880 (4673768) 4673768..4673941 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QQA22_RS22885 (4673969) 4673969..4674265 - 297 WP_001317561.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QQA22_RS22890 (4674492) 4674492..4674764 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QQA22_RS22895 (4674776) 4674776..4675006 - 231 WP_000371717.1 4Fe-4S mono-cluster protein YjdI -
QQA22_RS22900 (4675186) 4675186..4676817 + 1632 WP_001216477.1 sensor histidine kinase -
QQA22_RS22905 (4676814) 4676814..4677533 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T283357 WP_001173343.1 NZ_CP126952:c4673941-4673768 [Escherichia coli O78:H4]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT283357 WP_001317561.1 NZ_CP126952:c4674265-4673969 [Escherichia coli O78:H4]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMSFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A1V2FLJ5

References