283356

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4452356..4453170 Replicon chromosome
Accession NZ_CP126952
Organism Escherichia coli O78:H4 strain APEC E12049

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag QQA22_RS21770 Protein ID WP_001054376.1
Coordinates 4452356..4452613 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag QQA22_RS21775 Protein ID WP_001309181.1
Coordinates 4452625..4453170 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA22_RS21745 (4447644) 4447644..4448750 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
QQA22_RS21750 (4448815) 4448815..4449795 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
QQA22_RS21755 (4449905) 4449905..4450110 + 206 Protein_4257 HNH endonuclease -
QQA22_RS21760 (4450378) 4450378..4451618 - 1241 Protein_4258 helicase YjhR -
QQA22_RS21765 (4451734) 4451734..4451865 + 132 WP_001309182.1 hypothetical protein -
QQA22_RS21770 (4452356) 4452356..4452613 + 258 WP_001054376.1 YjhX family toxin Toxin
QQA22_RS21775 (4452625) 4452625..4453170 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
QQA22_RS21780 (4453226) 4453226..4453972 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
QQA22_RS21785 (4454141) 4454141..4454359 + 219 Protein_4263 hypothetical protein -
QQA22_RS21790 (4454397) 4454397..4454513 + 117 Protein_4264 VOC family protein -
QQA22_RS21795 (4454758) 4454758..4455879 + 1122 WP_000010829.1 M42 family metallopeptidase -
QQA22_RS21800 (4455876) 4455876..4456154 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
QQA22_RS21805 (4456166) 4456166..4457479 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 4442141..4468860 26719


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T283356 WP_001054376.1 NZ_CP126952:4452356-4452613 [Escherichia coli O78:H4]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT283356 WP_001309181.1 NZ_CP126952:4452625-4453170 [Escherichia coli O78:H4]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References