283354

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3886005..3886840 Replicon chromosome
Accession NZ_CP126952
Organism Escherichia coli O78:H4 strain APEC E12049

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7W4PV54
Locus tag QQA22_RS19095 Protein ID WP_000854821.1
Coordinates 3886005..3886382 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M0D404
Locus tag QQA22_RS19100 Protein ID WP_024214935.1
Coordinates 3886472..3886840 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA22_RS19065 (3881607) 3881607..3882101 + 495 WP_001059463.1 MarR family transcriptional regulator -
QQA22_RS19070 (3882539) 3882539..3882874 - 336 Protein_3731 Arm DNA-binding domain-containing protein -
QQA22_RS19075 (3883241) 3883241..3884560 + 1320 WP_000144688.1 site-specific integrase -
QQA22_RS19080 (3884653) 3884653..3885501 - 849 WP_001280470.1 DUF4942 domain-containing protein -
QQA22_RS19085 (3885586) 3885586..3885783 - 198 WP_089075429.1 DUF957 domain-containing protein -
QQA22_RS19090 (3885811) 3885811..3886008 - 198 Protein_3735 DUF5983 family protein -
QQA22_RS19095 (3886005) 3886005..3886382 - 378 WP_000854821.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
QQA22_RS19100 (3886472) 3886472..3886840 - 369 WP_024214935.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QQA22_RS19105 (3886920) 3886920..3887141 - 222 WP_000692350.1 DUF987 domain-containing protein -
QQA22_RS19110 (3887228) 3887228..3887704 - 477 WP_001186745.1 RadC family protein -
QQA22_RS19115 (3887720) 3887720..3888205 - 486 WP_024214936.1 antirestriction protein -
QQA22_RS19120 (3888297) 3888297..3889061 - 765 WP_289245668.1 DUF932 domain-containing protein -
QQA22_RS19125 (3889264) 3889264..3890805 + 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
QQA22_RS19130 (3890820) 3890820..3891566 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13930.95 Da        Isoelectric Point: 8.5163

>T283354 WP_000854821.1 NZ_CP126952:c3886382-3886005 [Escherichia coli O78:H4]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13605.41 Da        Isoelectric Point: 6.4659

>AT283354 WP_024214935.1 NZ_CP126952:c3886840-3886472 [Escherichia coli O78:H4]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W4PV54

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0D404

References