Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3679317..3679935 Replicon chromosome
Accession NZ_CP126952
Organism Escherichia coli O78:H4 strain APEC E12049

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QQA22_RS18130 Protein ID WP_001291435.1
Coordinates 3679717..3679935 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A8S7S0Y3
Locus tag QQA22_RS18125 Protein ID WP_039004128.1
Coordinates 3679317..3679691 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA22_RS18115 (3674406) 3674406..3675599 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QQA22_RS18120 (3675622) 3675622..3678771 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QQA22_RS18125 (3679317) 3679317..3679691 + 375 WP_039004128.1 Hha toxicity modulator TomB Antitoxin
QQA22_RS18130 (3679717) 3679717..3679935 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QQA22_RS18135 (3680107) 3680107..3680658 + 552 WP_000102564.1 maltose O-acetyltransferase -
QQA22_RS18140 (3680774) 3680774..3681244 + 471 WP_000136192.1 YlaC family protein -
QQA22_RS18145 (3681408) 3681408..3682958 + 1551 WP_001317659.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QQA22_RS18150 (3683000) 3683000..3683353 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QQA22_RS18160 (3683732) 3683732..3684043 + 312 WP_000409911.1 MGMT family protein -
QQA22_RS18165 (3684074) 3684074..3684646 - 573 WP_000779821.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T283353 WP_001291435.1 NZ_CP126952:3679717-3679935 [Escherichia coli O78:H4]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14587.42 Da        Isoelectric Point: 4.7395

>AT283353 WP_039004128.1 NZ_CP126952:3679317-3679691 [Escherichia coli O78:H4]
MDEYSPKRHDITQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References