Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3261949..3262654 Replicon chromosome
Accession NZ_CP126952
Organism Escherichia coli O78:H4 strain APEC E12049

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag QQA22_RS15940 Protein ID WP_289245592.1
Coordinates 3261949..3262335 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QQA22_RS15945 Protein ID WP_001280945.1
Coordinates 3262325..3262654 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA22_RS15920 (3257953) 3257953..3258579 + 627 WP_001295292.1 glutathione S-transferase GstB -
QQA22_RS15925 (3258576) 3258576..3259691 - 1116 Protein_3118 aldose sugar dehydrogenase YliI -
QQA22_RS15930 (3259802) 3259802..3260185 - 384 WP_000497137.1 biofilm formation regulator BssR -
QQA22_RS15935 (3260398) 3260398..3261723 + 1326 WP_000049378.1 30S ribosomal protein S12 methylthiotransferase RimO -
QQA22_RS15940 (3261949) 3261949..3262335 + 387 WP_289245592.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QQA22_RS15945 (3262325) 3262325..3262654 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
QQA22_RS15950 (3262724) 3262724..3264052 - 1329 WP_000086919.1 GGDEF domain-containing protein -
QQA22_RS15955 (3264060) 3264060..3266408 - 2349 Protein_3124 EAL domain-containing protein -
QQA22_RS15960 (3266586) 3266586..3267497 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14305.51 Da        Isoelectric Point: 9.9296

>T283351 WP_289245592.1 NZ_CP126952:3261949-3262335 [Escherichia coli O78:H4]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGIKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT283351 WP_001280945.1 NZ_CP126952:3262325-3262654 [Escherichia coli O78:H4]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References