283350

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3010644..3011428 Replicon chromosome
Accession NZ_CP126952
Organism Escherichia coli O78:H4 strain APEC E12049

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag QQA22_RS14740 Protein ID WP_000613624.1
Coordinates 3010934..3011428 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag QQA22_RS14735 Protein ID WP_039004735.1
Coordinates 3010644..3010937 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA22_RS14725 (3005793) 3005793..3006752 - 960 WP_000846329.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -
QQA22_RS14730 (3007325) 3007325..3010510 + 3186 WP_039004731.1 ribonuclease E -
QQA22_RS14735 (3010644) 3010644..3010937 + 294 WP_039004735.1 DUF1778 domain-containing protein Antitoxin
QQA22_RS14740 (3010934) 3010934..3011428 + 495 WP_000613624.1 GNAT family N-acetyltransferase Toxin
QQA22_RS14745 (3011523) 3011523..3012476 - 954 WP_001212762.1 flagellar hook-associated protein FlgL -
QQA22_RS14750 (3012488) 3012488..3014131 - 1644 WP_000096482.1 flagellar hook-associated protein FlgK -
QQA22_RS14755 (3014197) 3014197..3015138 - 942 WP_001317765.1 flagellar assembly peptidoglycan hydrolase FlgJ -
QQA22_RS14760 (3015138) 3015138..3016235 - 1098 WP_000589326.1 flagellar basal body P-ring protein FlgI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18142.04 Da        Isoelectric Point: 7.7444

>T283350 WP_000613624.1 NZ_CP126952:3010934-3011428 [Escherichia coli O78:H4]
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIDRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11069.63 Da        Isoelectric Point: 10.5423

>AT283350 WP_039004735.1 NZ_CP126952:3010644-3010937 [Escherichia coli O78:H4]
MPAANNISARRESLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References