Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2601784..2602420 Replicon chromosome
Accession NZ_CP126952
Organism Escherichia coli O78:H4 strain APEC E12049

Toxin (Protein)


Gene name hicA Uniprot ID A0A5F1EUB3
Locus tag QQA22_RS12560 Protein ID WP_000813796.1
Coordinates 2602244..2602420 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QQA22_RS12555 Protein ID WP_076838470.1
Coordinates 2601784..2602200 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA22_RS12535 (2596936) 2596936..2597877 - 942 WP_001251307.1 ABC transporter permease -
QQA22_RS12540 (2597878) 2597878..2598891 - 1014 WP_289245583.1 ABC transporter ATP-binding protein -
QQA22_RS12545 (2598909) 2598909..2600054 - 1146 WP_000047448.1 ABC transporter substrate-binding protein -
QQA22_RS12550 (2600299) 2600299..2601705 - 1407 WP_000760605.1 PLP-dependent aminotransferase family protein -
QQA22_RS12555 (2601784) 2601784..2602200 - 417 WP_076838470.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QQA22_RS12560 (2602244) 2602244..2602420 - 177 WP_000813796.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QQA22_RS12565 (2602642) 2602642..2602872 + 231 WP_000494243.1 YncJ family protein -
QQA22_RS12570 (2602964) 2602964..2604925 - 1962 WP_001317809.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QQA22_RS12575 (2604998) 2604998..2605534 - 537 WP_000429147.1 DNA-binding transcriptional regulator SutR -
QQA22_RS12580 (2605626) 2605626..2606798 + 1173 WP_001236216.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6751.78 Da        Isoelectric Point: 11.5666

>T283349 WP_000813796.1 NZ_CP126952:c2602420-2602244 [Escherichia coli O78:H4]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPSDEIKEPLRKAILKQLGLN

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15219.59 Da        Isoelectric Point: 4.5908

>AT283349 WP_076838470.1 NZ_CP126952:c2602200-2601784 [Escherichia coli O78:H4]
MRYPVTLTPAPEGGYVVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLTNNDHFIEVPLSIASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5F1EUB3

Antitoxin

Source ID Structure

References