Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2516506..2518088 Replicon chromosome
Accession NZ_CP126952
Organism Escherichia coli O78:H4 strain APEC E12049

Toxin (Protein)


Gene name hipA Uniprot ID A0A0J2BJD7
Locus tag QQA22_RS12205 Protein ID WP_001125469.1
Coordinates 2516772..2518088 (+) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QQA22_RS12200 Protein ID WP_001296726.1
Coordinates 2516506..2516772 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA22_RS12185 (2511650) 2511650..2512603 + 954 WP_000154356.1 transcriptional regulator LsrR -
QQA22_RS12190 (2512682) 2512682..2514274 + 1593 WP_000113152.1 autoinducer-2 kinase -
QQA22_RS12195 (2514424) 2514424..2516313 + 1890 Protein_2381 autotransporter barrel domain-containing lipoprotein -
QQA22_RS12200 (2516506) 2516506..2516772 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QQA22_RS12205 (2516772) 2516772..2518088 + 1317 WP_001125469.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QQA22_RS12210 (2518364) 2518364..2518630 + 267 Protein_2384 AraC family transcriptional regulator -
QQA22_RS12215 (2519064) 2519064..2519627 + 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
QQA22_RS12220 (2519989) 2519989..2520699 + 711 WP_001195165.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49275.91 Da        Isoelectric Point: 8.8783

>T283348 WP_001125469.1 NZ_CP126952:2516772-2518088 [Escherichia coli O78:H4]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPQVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHRRLSREWY

Download         Length: 1317 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT283348 WP_001296726.1 NZ_CP126952:2516506-2516772 [Escherichia coli O78:H4]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2BJD7

Antitoxin

Source ID Structure

References