Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1425023..1425648 Replicon chromosome
Accession NZ_CP126952
Organism Escherichia coli O78:H4 strain APEC E12049

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag QQA22_RS06825 Protein ID WP_000911329.1
Coordinates 1425250..1425648 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QQA22_RS06820 Protein ID WP_000450524.1
Coordinates 1425023..1425250 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA22_RS06795 (1420823) 1420823..1421293 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
QQA22_RS06800 (1421293) 1421293..1421865 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QQA22_RS06805 (1422011) 1422011..1422889 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
QQA22_RS06810 (1422906) 1422906..1423940 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
QQA22_RS06815 (1424153) 1424153..1424866 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QQA22_RS06820 (1425023) 1425023..1425250 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QQA22_RS06825 (1425250) 1425250..1425648 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
QQA22_RS06830 (1425795) 1425795..1426658 + 864 WP_001267498.1 neutral zinc metallopeptidase -
QQA22_RS06835 (1426673) 1426673..1428688 + 2016 WP_000829310.1 tRNA cytosine(34) acetyltransferase TmcA -
QQA22_RS06840 (1428762) 1428762..1429460 + 699 WP_000679819.1 esterase -
QQA22_RS06845 (1429541) 1429541..1429741 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T283341 WP_000911329.1 NZ_CP126952:1425250-1425648 [Escherichia coli O78:H4]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT283341 WP_000450524.1 NZ_CP126952:1425023-1425250 [Escherichia coli O78:H4]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References