Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 987492..988146 Replicon chromosome
Accession NZ_CP126952
Organism Escherichia coli O78:H4 strain APEC E12049

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag QQA22_RS04850 Protein ID WP_000244781.1
Coordinates 987739..988146 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QQA22_RS04845 Protein ID WP_000354046.1
Coordinates 987492..987758 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA22_RS04825 (983570) 983570..985003 - 1434 WP_001389468.1 6-phospho-beta-glucosidase BglA -
QQA22_RS04830 (985048) 985048..985359 + 312 WP_001182953.1 N(4)-acetylcytidine aminohydrolase -
QQA22_RS04835 (985523) 985523..986182 + 660 WP_000250269.1 hemolysin III family protein -
QQA22_RS04840 (986259) 986259..987239 - 981 WP_000886050.1 tRNA-modifying protein YgfZ -
QQA22_RS04845 (987492) 987492..987758 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QQA22_RS04850 (987739) 987739..988146 + 408 WP_000244781.1 protein YgfX Toxin
QQA22_RS04855 (988186) 988186..988707 - 522 WP_001055874.1 flavodoxin FldB -
QQA22_RS04860 (988819) 988819..989715 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QQA22_RS04865 (989740) 989740..990450 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QQA22_RS04870 (990456) 990456..992189 + 1734 WP_000813191.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T283340 WP_000244781.1 NZ_CP126952:987739-988146 [Escherichia coli O78:H4]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT283340 WP_000354046.1 NZ_CP126952:987492-987758 [Escherichia coli O78:H4]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References