283335

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 344276..344907 Replicon chromosome
Accession NZ_CP126952
Organism Escherichia coli O78:H4 strain APEC E12049

Toxin (Protein)


Gene name hicA Uniprot ID L4J012
Locus tag QQA22_RS01660 Protein ID WP_001260301.1
Coordinates 344632..344907 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IZA1
Locus tag QQA22_RS01655 Protein ID WP_000593557.1
Coordinates 344276..344635 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA22_RS01630 (340408) 340408..341352 + 945 WP_000947063.1 nickel ABC transporter permease subunit NikB -
QQA22_RS01635 (341349) 341349..342182 + 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
QQA22_RS01640 (342182) 342182..342946 + 765 WP_001136206.1 nickel import ATP-binding protein NikD -
QQA22_RS01645 (342943) 342943..343749 + 807 WP_000173650.1 nickel import ATP-binding protein NikE -
QQA22_RS01650 (343755) 343755..344156 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
QQA22_RS01655 (344276) 344276..344635 - 360 WP_000593557.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QQA22_RS01660 (344632) 344632..344907 - 276 WP_001260301.1 type II toxin-antitoxin system HicA family toxin Toxin
QQA22_RS01665 (344980) 344980..346104 - 1125 WP_001318088.1 ABC transporter permease -
QQA22_RS01670 (346104) 346104..348839 - 2736 WP_000149178.1 ribosome-associated ATPase/putative transporter RbbA -
QQA22_RS01675 (348836) 348836..349903 - 1068 WP_000361470.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10185.87 Da        Isoelectric Point: 10.6128

>T283335 WP_001260301.1 NZ_CP126952:c344907-344632 [Escherichia coli O78:H4]
MRTQVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13389.28 Da        Isoelectric Point: 5.1987

>AT283335 WP_000593557.1 NZ_CP126952:c344635-344276 [Escherichia coli O78:H4]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLTNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L4J012

Antitoxin

Source ID Structure
AlphaFold DB L4IZA1

References