283334

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 317051..317646 Replicon chromosome
Accession NZ_CP126952
Organism Escherichia coli O78:H4 strain APEC E12049

Toxin (Protein)


Gene name doc Uniprot ID D6JG31
Locus tag QQA22_RS01505 Protein ID WP_000155159.1
Coordinates 317051..317428 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID D6JG32
Locus tag QQA22_RS01510 Protein ID WP_000557315.1
Coordinates 317425..317646 (-) Length 74 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA22_RS01485 (312550) 312550..313619 - 1070 Protein_293 sn-glycerol 3-phosphate ABC transporter ATP binding protein UgpC -
QQA22_RS01490 (313621) 313621..314466 - 846 WP_000572164.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
QQA22_RS01495 (314463) 314463..315350 - 888 WP_000099289.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
QQA22_RS01500 (315526) 315526..316842 - 1317 WP_000803191.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
QQA22_RS01505 (317051) 317051..317428 - 378 WP_000155159.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
QQA22_RS01510 (317425) 317425..317646 - 222 WP_000557315.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QQA22_RS01515 (317734) 317734..318447 - 714 WP_000416895.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
QQA22_RS01520 (318449) 318449..319216 - 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
QQA22_RS01525 (319213) 319213..320490 - 1278 WP_000803825.1 branched chain amino acid ABC transporter permease LivM -
QQA22_RS01530 (320487) 320487..321413 - 927 WP_000003010.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QQA22_RS01535 (321461) 321461..322570 - 1110 WP_001318085.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 311810..320490 8680


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(27-86)

Antitoxin

(1-53)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 13964.25 Da        Isoelectric Point: 6.7263

>T283334 WP_000155159.1 NZ_CP126952:c317428-317051 [Escherichia coli O78:H4]
MTIQFISAEEIIYFHDKLLSVTPGVTGMSDPGRAEALLYRVLNKYEYEGVSDLWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILAANPEFVELTVDVAAGKVSLEDIVTRLRQRGT

Download         Length: 378 bp


Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8103.24 Da        Isoelectric Point: 6.2168

>AT283334 WP_000557315.1 NZ_CP126952:c317646-317425 [Escherichia coli O78:H4]
MHTMNYSEARQNLALVLETAATGTPVTITRRGHKAAVIISAEEFERYQKAKLDAEFDAIMAIHGSEIKELADK

Download         Length: 222 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB D6JG31


Antitoxin

Source ID Structure
AlphaFold DB D6JG32

References