Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 12823..13370 Replicon plasmid pEND_Eco 14033-2
Accession NZ_CP126950
Organism Escherichia coli O78:H4 strain APEC E14033

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag QQA23_RS25260 Protein ID WP_244442846.1
Coordinates 13092..13370 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag QQA23_RS25255 Protein ID WP_000079941.1
Coordinates 12823..13092 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA23_RS25230 (8467) 8467..9000 - 534 WP_001303319.1 transcription termination/antitermination NusG family protein -
QQA23_RS25235 (9442) 9442..9729 - 288 WP_000074849.1 conjugal transfer protein TraA -
QQA23_RS25240 (9647) 9647..9877 - 231 WP_228772074.1 ash family protein -
QQA23_RS25245 (10883) 10883..11914 + 1032 WP_000907873.1 plasmid replication initiator RepA -
QQA23_RS25250 (12610) 12610..12768 + 159 WP_000841008.1 hypothetical protein -
QQA23_RS25255 (12823) 12823..13092 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QQA23_RS25260 (13092) 13092..13370 + 279 WP_244442846.1 type II toxin-antitoxin system toxin YacB Toxin
QQA23_RS25265 (13410) 13410..14258 + 849 WP_001057996.1 3'-5' exonuclease -
QQA23_RS25270 (14375) 14375..14848 + 474 WP_001334658.1 hypothetical protein -
QQA23_RS25275 (15325) 15325..15591 - 267 WP_000955263.1 hypothetical protein -
QQA23_RS25280 (15591) 15591..16085 - 495 WP_001459505.1 hypothetical protein -
QQA23_RS25285 (16141) 16141..16743 - 603 WP_000517695.1 ProQ/FINO family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B / aac(3)-IId / blaCTX-M-14 - 1..115173 115173


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10761.43 Da        Isoelectric Point: 9.7617

>T283327 WP_244442846.1 NZ_CP126950:13092-13370 [Escherichia coli O78:H4]
MEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT283327 WP_000079941.1 NZ_CP126950:12823-13092 [Escherichia coli O78:H4]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References