Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4526198..4526695 Replicon chromosome
Accession NZ_CP126948
Organism Escherichia coli O78:H4 strain APEC E14033

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QQA23_RS22145 Protein ID WP_001173343.1
Coordinates 4526198..4526371 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID A0A1V2FLJ5
Locus tag QQA23_RS22150 Protein ID WP_001317561.1
Coordinates 4526399..4526695 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA23_RS22135 (4522868) 4522868..4524325 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
QQA23_RS22140 (4524562) 4524562..4526079 + 1518 WP_000003805.1 lysine--tRNA ligase -
QQA23_RS22145 (4526198) 4526198..4526371 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QQA23_RS22150 (4526399) 4526399..4526695 - 297 WP_001317561.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QQA23_RS22155 (4526922) 4526922..4527194 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QQA23_RS22160 (4527206) 4527206..4527436 - 231 WP_000371717.1 4Fe-4S mono-cluster protein YjdI -
QQA23_RS22165 (4527616) 4527616..4529247 + 1632 WP_001216477.1 sensor histidine kinase -
QQA23_RS22170 (4529244) 4529244..4529963 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island ant(3'')-Ia / qacE / sul1 sfaX / papF / papE / papK / papJ / papD / papC / papH / papB / papI 4446890..4526695 79805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T283325 WP_001173343.1 NZ_CP126948:c4526371-4526198 [Escherichia coli O78:H4]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT283325 WP_001317561.1 NZ_CP126948:c4526695-4526399 [Escherichia coli O78:H4]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMSFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A1V2FLJ5

References