Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3619656..3620274 Replicon chromosome
Accession NZ_CP126948
Organism Escherichia coli O78:H4 strain APEC E14033

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QQA23_RS17865 Protein ID WP_001291435.1
Coordinates 3620056..3620274 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QQA23_RS17860 Protein ID WP_000344800.1
Coordinates 3619656..3620030 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA23_RS17850 (3614745) 3614745..3615938 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QQA23_RS17855 (3615961) 3615961..3619110 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QQA23_RS17860 (3619656) 3619656..3620030 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QQA23_RS17865 (3620056) 3620056..3620274 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QQA23_RS17870 (3620446) 3620446..3620997 + 552 WP_000102564.1 maltose O-acetyltransferase -
QQA23_RS17875 (3621113) 3621113..3621583 + 471 WP_000136192.1 YlaC family protein -
QQA23_RS17880 (3621747) 3621747..3623297 + 1551 WP_001317659.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QQA23_RS17885 (3623339) 3623339..3623692 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QQA23_RS17895 (3624071) 3624071..3624382 + 312 WP_000409911.1 MGMT family protein -
QQA23_RS17900 (3624413) 3624413..3624985 - 573 WP_000779821.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T283322 WP_001291435.1 NZ_CP126948:3620056-3620274 [Escherichia coli O78:H4]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT283322 WP_000344800.1 NZ_CP126948:3619656-3620030 [Escherichia coli O78:H4]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References