Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2953501..2954285 Replicon chromosome
Accession NZ_CP126948
Organism Escherichia coli O78:H4 strain APEC E14033

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag QQA23_RS14480 Protein ID WP_000613624.1
Coordinates 2953791..2954285 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B1LI61
Locus tag QQA23_RS14475 Protein ID WP_001110446.1
Coordinates 2953501..2953794 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA23_RS14465 (2948650) 2948650..2949609 - 960 WP_000846329.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -
QQA23_RS14470 (2950182) 2950182..2953367 + 3186 WP_000827395.1 ribonuclease E -
QQA23_RS14475 (2953501) 2953501..2953794 + 294 WP_001110446.1 DUF1778 domain-containing protein Antitoxin
QQA23_RS14480 (2953791) 2953791..2954285 + 495 WP_000613624.1 GNAT family N-acetyltransferase Toxin
QQA23_RS14485 (2954380) 2954380..2955333 - 954 WP_001212762.1 flagellar hook-associated protein FlgL -
QQA23_RS14490 (2955345) 2955345..2956988 - 1644 WP_000096482.1 flagellar hook-associated protein FlgK -
QQA23_RS14495 (2957054) 2957054..2957995 - 942 WP_001317765.1 flagellar assembly peptidoglycan hydrolase FlgJ -
QQA23_RS14500 (2957995) 2957995..2959092 - 1098 WP_000589326.1 flagellar basal body P-ring protein FlgI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18142.04 Da        Isoelectric Point: 7.7444

>T283319 WP_000613624.1 NZ_CP126948:2953791-2954285 [Escherichia coli O78:H4]
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIDRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11079.67 Da        Isoelectric Point: 10.5423

>AT283319 WP_001110446.1 NZ_CP126948:2953501-2953794 [Escherichia coli O78:H4]
MPAANNIPARRESLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829G775

References