Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2495944..2497526 Replicon chromosome
Accession NZ_CP126948
Organism Escherichia coli O78:H4 strain APEC E14033

Toxin (Protein)


Gene name hipA Uniprot ID A0A0J2BJD7
Locus tag QQA23_RS12195 Protein ID WP_001125469.1
Coordinates 2496210..2497526 (+) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QQA23_RS12190 Protein ID WP_001296726.1
Coordinates 2495944..2496210 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA23_RS12175 (2491088) 2491088..2492041 + 954 WP_000154356.1 transcriptional regulator LsrR -
QQA23_RS12180 (2492120) 2492120..2493712 + 1593 WP_000113152.1 autoinducer-2 kinase -
QQA23_RS12185 (2493862) 2493862..2495751 + 1890 Protein_2386 autotransporter barrel domain-containing lipoprotein -
QQA23_RS12190 (2495944) 2495944..2496210 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QQA23_RS12195 (2496210) 2496210..2497526 + 1317 WP_001125469.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QQA23_RS12200 (2497802) 2497802..2498068 + 267 Protein_2389 AraC family transcriptional regulator -
QQA23_RS12205 (2498502) 2498502..2499065 + 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
QQA23_RS12210 (2499427) 2499427..2500137 + 711 WP_001195165.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49275.91 Da        Isoelectric Point: 8.8783

>T283317 WP_001125469.1 NZ_CP126948:2496210-2497526 [Escherichia coli O78:H4]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPQVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHRRLSREWY

Download         Length: 1317 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT283317 WP_001296726.1 NZ_CP126948:2495944-2496210 [Escherichia coli O78:H4]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2BJD7

Antitoxin

Source ID Structure

References