Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1391685..1392310 Replicon chromosome
Accession NZ_CP126948
Organism Escherichia coli O78:H4 strain APEC E14033

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag QQA23_RS06675 Protein ID WP_000911329.1
Coordinates 1391912..1392310 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QQA23_RS06670 Protein ID WP_000450524.1
Coordinates 1391685..1391912 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA23_RS06645 (1387485) 1387485..1387955 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
QQA23_RS06650 (1387955) 1387955..1388527 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QQA23_RS06655 (1388673) 1388673..1389551 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
QQA23_RS06660 (1389568) 1389568..1390602 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
QQA23_RS06665 (1390815) 1390815..1391528 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QQA23_RS06670 (1391685) 1391685..1391912 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QQA23_RS06675 (1391912) 1391912..1392310 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
QQA23_RS06680 (1392457) 1392457..1393320 + 864 WP_001267498.1 neutral zinc metallopeptidase -
QQA23_RS06685 (1393335) 1393335..1395350 + 2016 WP_000829310.1 tRNA cytosine(34) acetyltransferase TmcA -
QQA23_RS06690 (1395424) 1395424..1396122 + 699 WP_000679819.1 esterase -
QQA23_RS06695 (1396203) 1396203..1396403 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T283310 WP_000911329.1 NZ_CP126948:1391912-1392310 [Escherichia coli O78:H4]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT283310 WP_000450524.1 NZ_CP126948:1391685-1391912 [Escherichia coli O78:H4]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References