Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 957103..957757 Replicon chromosome
Accession NZ_CP126948
Organism Escherichia coli O78:H4 strain APEC E14033

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag QQA23_RS04705 Protein ID WP_000244781.1
Coordinates 957350..957757 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QQA23_RS04700 Protein ID WP_000354046.1
Coordinates 957103..957369 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA23_RS04680 (953181) 953181..954614 - 1434 WP_001389468.1 6-phospho-beta-glucosidase BglA -
QQA23_RS04685 (954659) 954659..954970 + 312 WP_001182953.1 N(4)-acetylcytidine aminohydrolase -
QQA23_RS04690 (955134) 955134..955793 + 660 WP_000250269.1 hemolysin III family protein -
QQA23_RS04695 (955870) 955870..956850 - 981 WP_000886050.1 tRNA-modifying protein YgfZ -
QQA23_RS04700 (957103) 957103..957369 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QQA23_RS04705 (957350) 957350..957757 + 408 WP_000244781.1 protein YgfX Toxin
QQA23_RS04710 (957797) 957797..958318 - 522 WP_001055874.1 flavodoxin FldB -
QQA23_RS04715 (958430) 958430..959326 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QQA23_RS04720 (959351) 959351..960061 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QQA23_RS04725 (960067) 960067..961800 + 1734 WP_000813191.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T283309 WP_000244781.1 NZ_CP126948:957350-957757 [Escherichia coli O78:H4]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT283309 WP_000354046.1 NZ_CP126948:957103-957369 [Escherichia coli O78:H4]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References