Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 293732..294327 Replicon chromosome
Accession NZ_CP126948
Organism Escherichia coli O78:H4 strain APEC E14033

Toxin (Protein)


Gene name doc Uniprot ID D6JG31
Locus tag QQA23_RS01370 Protein ID WP_000155159.1
Coordinates 293950..294327 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID D6JG32
Locus tag QQA23_RS01365 Protein ID WP_000557315.1
Coordinates 293732..293953 (+) Length 74 a.a.

Genomic Context


QQA23_RS01340QQA23_RS01345QQA23_RS01350QQA23_RS01355QQA23_RS01360QQA23_RS01365QQA23_RS01370QQA23_RS01375QQA23_RS01380QQA23_RS01385QQA23_RS01390
Location: 288808..289917 (1110 bp)
Type: Others
Protein ID: WP_001318085.1
Location: 289965..290891 (927 bp)
Type: Others
Protein ID: WP_000003010.1
Location: 290888..292165 (1278 bp)
Type: Others
Protein ID: WP_000803825.1
Location: 292162..292929 (768 bp)
Type: Others
Protein ID: WP_000082101.1
Location: 292931..293644 (714 bp)
Type: Others
Protein ID: WP_000416895.1
Location: 293732..293953 (222 bp)
Type: Antitoxin
Protein ID: WP_000557315.1
Location: 293950..294327 (378 bp)
Type: Toxin
Protein ID: WP_000155159.1
Location: 294536..295852 (1317 bp)
Type: Others
Protein ID: WP_000803191.1
Location: 296028..296915 (888 bp)
Type: Others
Protein ID: WP_000099289.1
Location: 296912..297757 (846 bp)
Type: Others
Protein ID: WP_000572164.1
Location: 297759..298829 (1071 bp)
Type: Others
Protein ID: WP_000907828.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
QQA23_RS01340 (288808)288808..289917+1110WP_001318085.1high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK-
QQA23_RS01345 (289965)289965..290891+927WP_000003010.1high-affinity branched-chain amino acid ABC transporter permease LivH-
QQA23_RS01350 (290888)290888..292165+1278WP_000803825.1branched chain amino acid ABC transporter permease LivM-
QQA23_RS01355 (292162)292162..292929+768WP_000082101.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG-
QQA23_RS01360 (292931)292931..293644+714WP_000416895.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF-
QQA23_RS01365 (293732)293732..293953+222WP_000557315.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
QQA23_RS01370 (293950)293950..294327+378WP_000155159.1type II toxin-antitoxin system death-on-curing family toxinToxin
QQA23_RS01375 (294536)294536..295852+1317WP_000803191.1sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB-
QQA23_RS01380 (296028)296028..296915+888WP_000099289.1sn-glycerol-3-phosphate ABC transporter permease UgpA-
QQA23_RS01385 (296912)296912..297757+846WP_000572164.1sn-glycerol-3-phosphate ABC transporter permease UgpE-
QQA23_RS01390 (297759)297759..298829+1071WP_000907828.1sn-glycerol 3-phosphate ABC transporter ATP binding protein UgpC-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--290888..2995698681


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(27-86)

Antitoxin

(1-53)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 13964.25 Da        Isoelectric Point: 6.7263

>T283306 WP_000155159.1 NZ_CP126948:293950-294327 [Escherichia coli O78:H4]
MTIQFISAEEIIYFHDKLLSVTPGVTGMSDPGRAEALLYRVLNKYEYEGVSDLWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILAANPEFVELTVDVAAGKVSLEDIVTRLRQRGT

Download         Length: 378 bp


Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8103.24 Da        Isoelectric Point: 6.2168

>AT283306 WP_000557315.1 NZ_CP126948:293732-293953 [Escherichia coli O78:H4]
MHTMNYSEARQNLALVLETAATGTPVTITRRGHKAAVIISAEEFERYQKAKLDAEFDAIMAIHGSEIKELADK

Download         Length: 222 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBD6JG31


Antitoxin

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Source
ID
Structure
AlphaFold DBD6JG32

References