Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 266456..267087 Replicon chromosome
Accession NZ_CP126948
Organism Escherichia coli O78:H4 strain APEC E14033

Toxin (Protein)


Gene name hicA Uniprot ID L4J012
Locus tag QQA23_RS01215 Protein ID WP_001260301.1
Coordinates 266456..266731 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IZA1
Locus tag QQA23_RS01220 Protein ID WP_000593557.1
Coordinates 266728..267087 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA23_RS01200 (261460) 261460..262527 + 1068 WP_000361470.1 HlyD family secretion protein -
QQA23_RS01205 (262524) 262524..265259 + 2736 WP_000149178.1 ribosome-associated ATPase/putative transporter RbbA -
QQA23_RS01210 (265259) 265259..266383 + 1125 WP_001318088.1 ABC transporter permease -
QQA23_RS01215 (266456) 266456..266731 + 276 WP_001260301.1 type II toxin-antitoxin system HicA family toxin Toxin
QQA23_RS01220 (266728) 266728..267087 + 360 WP_000593557.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QQA23_RS01225 (267207) 267207..267608 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
QQA23_RS01230 (267614) 267614..268420 - 807 WP_000173650.1 nickel import ATP-binding protein NikE -
QQA23_RS01235 (268417) 268417..269181 - 765 WP_001136206.1 nickel import ATP-binding protein NikD -
QQA23_RS01240 (269181) 269181..270014 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
QQA23_RS01245 (270011) 270011..270955 - 945 WP_000947063.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10185.87 Da        Isoelectric Point: 10.6128

>T283305 WP_001260301.1 NZ_CP126948:266456-266731 [Escherichia coli O78:H4]
MRTQVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13389.28 Da        Isoelectric Point: 5.1987

>AT283305 WP_000593557.1 NZ_CP126948:266728-267087 [Escherichia coli O78:H4]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLTNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L4J012

Antitoxin

Source ID Structure
AlphaFold DB L4IZA1

References