Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 5101176..5102101 Replicon chromosome
Accession NZ_CP126946
Organism Escherichia coli O78:H51 strain APEC E18005

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag QQA24_RS24680 Protein ID WP_014640052.1
Coordinates 5101715..5102101 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag QQA24_RS24675 Protein ID WP_001339382.1
Coordinates 5101176..5101685 (+) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA24_RS24640 (5096195) 5096195..5096803 + 609 WP_000646078.1 transcriptional repressor LexA -
QQA24_RS24645 (5096876) 5096876..5098201 + 1326 WP_001298861.1 MATE family efflux transporter DinF -
QQA24_RS24650 (5098317) 5098317..5098526 + 210 WP_001030593.1 CsbD family protein -
QQA24_RS24655 (5098568) 5098568..5099083 - 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
QQA24_RS24660 (5099401) 5099401..5099655 + 255 WP_000912571.1 protein YjbL -
QQA24_RS24665 (5099679) 5099679..5100391 + 713 Protein_4813 DUF2713 family protein -
QQA24_RS24670 (5100755) 5100755..5100859 + 105 Protein_4814 tRNA-dihydrouridine synthase -
QQA24_RS24675 (5101176) 5101176..5101685 + 510 WP_001339382.1 Panacea domain-containing protein Antitoxin
QQA24_RS24680 (5101715) 5101715..5102101 + 387 WP_014640052.1 hypothetical protein Toxin
QQA24_RS24685 (5102141) 5102141..5102314 + 174 WP_000390072.1 hypothetical protein -
QQA24_RS24690 (5102362) 5102362..5102643 - 282 WP_001093917.1 pyocin activator PrtN family protein -
QQA24_RS24695 (5102680) 5102680..5103252 - 573 WP_001061348.1 3'-5' exonuclease -
QQA24_RS24700 (5103252) 5103252..5104061 - 810 WP_000206745.1 hypothetical protein -
QQA24_RS24705 (5104061) 5104061..5104423 - 363 WP_001565177.1 phage protein -
QQA24_RS24710 (5104414) 5104414..5104950 - 537 WP_000008210.1 5'-deoxynucleotidase -
QQA24_RS24715 (5105078) 5105078..5105902 - 825 WP_001569327.1 DUF2303 family protein -
QQA24_RS24720 (5105968) 5105968..5106330 - 363 WP_000135691.1 protein YfdP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5096195..5129304 33109


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(6-116)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T283293 WP_014640052.1 NZ_CP126946:5101715-5102101 [Escherichia coli O78:H51]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 19576.29 Da        Isoelectric Point: 5.3338

>AT283293 WP_001339382.1 NZ_CP126946:5101176-5101685 [Escherichia coli O78:H51]
MAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHNVSLRSDPREMDAD
EVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Download         Length: 510 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References