Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4363654..4364240 Replicon chromosome
Accession NZ_CP126946
Organism Escherichia coli O78:H51 strain APEC E18005

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag QQA24_RS21315 Protein ID WP_042014162.1
Coordinates 4364010..4364240 (-) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag QQA24_RS21310 Protein ID WP_000593555.1
Coordinates 4363654..4364013 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA24_RS21285 (4359786) 4359786..4360730 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
QQA24_RS21290 (4360727) 4360727..4361560 + 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
QQA24_RS21295 (4361560) 4361560..4362324 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
QQA24_RS21300 (4362321) 4362321..4363127 + 807 WP_000173666.1 nickel import ATP-binding protein NikE -
QQA24_RS21305 (4363133) 4363133..4363534 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
QQA24_RS21310 (4363654) 4363654..4364013 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QQA24_RS21315 (4364010) 4364010..4364240 - 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
QQA24_RS21320 (4364344) 4364344..4365468 - 1125 WP_001314210.1 ABC transporter permease -
QQA24_RS21325 (4365468) 4365468..4368203 - 2736 WP_000149165.1 ribosome-associated ATPase/putative transporter RbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T283290 WP_042014162.1 NZ_CP126946:c4364240-4364010 [Escherichia coli O78:H51]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT283290 WP_000593555.1 NZ_CP126946:c4364013-4363654 [Escherichia coli O78:H51]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References