Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 4342147..4342947 Replicon chromosome
Accession NZ_CP126946
Organism Escherichia coli O78:H51 strain APEC E18005

Toxin (Protein)


Gene name ataT Uniprot ID F4NNI0
Locus tag QQA24_RS21190 Protein ID WP_000342449.1
Coordinates 4342147..4342674 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag QQA24_RS21195 Protein ID WP_001277108.1
Coordinates 4342681..4342947 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA24_RS21165 (4337222) 4337222..4337989 - 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
QQA24_RS21170 (4337986) 4337986..4339263 - 1278 WP_000803771.1 branched chain amino acid ABC transporter permease LivM -
QQA24_RS21175 (4339260) 4339260..4340186 - 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QQA24_RS21180 (4340234) 4340234..4341343 - 1110 WP_000827696.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QQA24_RS21185 (4341767) 4341767..4342150 + 384 WP_000778795.1 aspartate 1-decarboxylase autocleavage activator PanM -
QQA24_RS21190 (4342147) 4342147..4342674 - 528 WP_000342449.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QQA24_RS21195 (4342681) 4342681..4342947 - 267 WP_001277108.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QQA24_RS21200 (4343097) 4343097..4344200 - 1104 WP_001021996.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QQA24_RS21205 (4344471) 4344471..4345325 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QQA24_RS21210 (4345570) 4345570..4346628 - 1059 WP_001042003.1 permease-like cell division protein FtsX -
QQA24_RS21215 (4346621) 4346621..4347289 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19691.70 Da        Isoelectric Point: 7.7457

>T283289 WP_000342449.1 NZ_CP126946:c4342674-4342147 [Escherichia coli O78:H51]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNKKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT283289 WP_001277108.1 NZ_CP126946:c4342947-4342681 [Escherichia coli O78:H51]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLZ4

Antitoxin

Source ID Structure
PDB 6GTS
PDB 6AJN
PDB 6GTQ
PDB 6GTO
PDB 6GTR
PDB 6AJM
AlphaFold DB A0A829CN24

References