Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3563539..3564122 Replicon chromosome
Accession NZ_CP126946
Organism Escherichia coli O78:H51 strain APEC E18005

Toxin (Protein)


Gene name mazF Uniprot ID U9XFN8
Locus tag QQA24_RS17315 Protein ID WP_000254745.1
Coordinates 3563539..3563874 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag QQA24_RS17320 Protein ID WP_000581937.1
Coordinates 3563874..3564122 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA24_RS17295 (3559008) 3559008..3559370 + 363 WP_000034929.1 hypothetical protein -
QQA24_RS17300 (3559426) 3559426..3560724 - 1299 WP_000036723.1 phosphopyruvate hydratase -
QQA24_RS17305 (3560812) 3560812..3562449 - 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
QQA24_RS17310 (3562677) 3562677..3563468 - 792 WP_001071648.1 nucleoside triphosphate pyrophosphohydrolase -
QQA24_RS17315 (3563539) 3563539..3563874 - 336 WP_000254745.1 endoribonuclease MazF Toxin
QQA24_RS17320 (3563874) 3563874..3564122 - 249 WP_000581937.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QQA24_RS17325 (3564200) 3564200..3566434 - 2235 WP_000226815.1 GTP pyrophosphokinase -
QQA24_RS17330 (3566482) 3566482..3567783 - 1302 WP_000046790.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12158.08 Da        Isoelectric Point: 8.4777

>T283285 WP_000254745.1 NZ_CP126946:c3563874-3563539 [Escherichia coli O78:H51]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPYTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT283285 WP_000581937.1 NZ_CP126946:c3564122-3563874 [Escherichia coli O78:H51]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYM3

Antitoxin

Source ID Structure
PDB 1UB4
PDB 5CQX
PDB 5CQY
PDB 1MVF
PDB 2MRN
PDB 2MRU
AlphaFold DB A0A7U9LMB4

References