Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3263976..3264601 Replicon chromosome
Accession NZ_CP126946
Organism Escherichia coli O78:H51 strain APEC E18005

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QQA24_RS15860 Protein ID WP_000911330.1
Coordinates 3263976..3264374 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QQA24_RS15865 Protein ID WP_000450524.1
Coordinates 3264374..3264601 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA24_RS15840 (3259854) 3259854..3260054 + 201 WP_000383836.1 YpfN family protein -
QQA24_RS15845 (3260164) 3260164..3260862 - 699 WP_000679823.1 esterase -
QQA24_RS15850 (3260936) 3260936..3262951 - 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
QQA24_RS15855 (3262966) 3262966..3263829 - 864 WP_001267508.1 neutral zinc metallopeptidase -
QQA24_RS15860 (3263976) 3263976..3264374 - 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
QQA24_RS15865 (3264374) 3264374..3264601 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QQA24_RS15870 (3264755) 3264755..3265468 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QQA24_RS15875 (3265681) 3265681..3266715 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
QQA24_RS15880 (3266732) 3266732..3267610 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
QQA24_RS15885 (3267756) 3267756..3268328 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QQA24_RS15890 (3268328) 3268328..3268798 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T283284 WP_000911330.1 NZ_CP126946:c3264374-3263976 [Escherichia coli O78:H51]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT283284 WP_000450524.1 NZ_CP126946:c3264601-3264374 [Escherichia coli O78:H51]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References