Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2036746..2037384 Replicon chromosome
Accession NZ_CP126946
Organism Escherichia coli O78:H51 strain APEC E18005

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QQA24_RS09935 Protein ID WP_000813794.1
Coordinates 2036746..2036922 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QQA24_RS09940 Protein ID WP_001270286.1
Coordinates 2036968..2037384 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA24_RS09915 (2032365) 2032365..2033540 - 1176 WP_001236319.1 BenE family transporter YdcO -
QQA24_RS09920 (2033632) 2033632..2034168 + 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
QQA24_RS09925 (2034241) 2034241..2036202 + 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QQA24_RS09930 (2036294) 2036294..2036524 - 231 WP_000494244.1 YncJ family protein -
QQA24_RS09935 (2036746) 2036746..2036922 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QQA24_RS09940 (2036968) 2036968..2037384 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QQA24_RS09945 (2037463) 2037463..2038869 + 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
QQA24_RS09950 (2039114) 2039114..2040259 + 1146 WP_000047456.1 ABC transporter substrate-binding protein -
QQA24_RS09955 (2040277) 2040277..2041290 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
QQA24_RS09960 (2041291) 2041291..2042232 + 942 WP_001251319.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2031060..2032325 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T283276 WP_000813794.1 NZ_CP126946:2036746-2036922 [Escherichia coli O78:H51]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT283276 WP_001270286.1 NZ_CP126946:2036968-2037384 [Escherichia coli O78:H51]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References