Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1005676..1006294 Replicon chromosome
Accession NZ_CP126946
Organism Escherichia coli O78:H51 strain APEC E18005

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QQA24_RS04850 Protein ID WP_001291435.1
Coordinates 1005676..1005894 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QQA24_RS04855 Protein ID WP_000344800.1
Coordinates 1005920..1006294 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA24_RS04815 (1000965) 1000965..1001537 + 573 WP_289257051.1 YbaY family lipoprotein -
QQA24_RS04820 (1001568) 1001568..1001879 - 312 WP_000409911.1 MGMT family protein -
QQA24_RS04830 (1002258) 1002258..1002611 + 354 WP_000878140.1 DUF1428 domain-containing protein -
QQA24_RS04835 (1002653) 1002653..1004203 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QQA24_RS04840 (1004367) 1004367..1004837 - 471 WP_000136192.1 YlaC family protein -
QQA24_RS04845 (1004953) 1004953..1005504 - 552 WP_000102568.1 maltose O-acetyltransferase -
QQA24_RS04850 (1005676) 1005676..1005894 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QQA24_RS04855 (1005920) 1005920..1006294 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QQA24_RS04860 (1006840) 1006840..1009989 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QQA24_RS04865 (1010012) 1010012..1011205 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T283270 WP_001291435.1 NZ_CP126946:c1005894-1005676 [Escherichia coli O78:H51]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT283270 WP_000344800.1 NZ_CP126946:c1006294-1005920 [Escherichia coli O78:H51]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References