283269

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 971380..972217 Replicon chromosome
Accession NZ_CP126946
Organism Escherichia coli O78:H51 strain APEC E18005

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag QQA24_RS04680 Protein ID WP_000227784.1
Coordinates 971380..971922 (-) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag QQA24_RS04685 Protein ID WP_001297137.1
Coordinates 971906..972217 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA24_RS04660 (966919) 966919..967830 - 912 WP_000705847.1 2-dehydropantoate 2-reductase -
QQA24_RS04665 (967998) 967998..968489 + 492 WP_001138904.1 nucleotide binding protein YajQ -
QQA24_RS04670 (968617) 968617..969981 - 1365 WP_001000978.1 MFS transporter -
QQA24_RS04675 (970389) 970389..971324 + 936 WP_001297127.1 tetratricopeptide repeat protein -
QQA24_RS04680 (971380) 971380..971922 - 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
QQA24_RS04685 (971906) 971906..972217 - 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
QQA24_RS04690 (972402) 972402..973292 - 891 WP_000971336.1 heme o synthase -
QQA24_RS04695 (973304) 973304..973633 - 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
QQA24_RS04700 (973633) 973633..974247 - 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
QQA24_RS04705 (974237) 974237..976228 - 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
QQA24_RS04710 (976250) 976250..977197 - 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T283269 WP_000227784.1 NZ_CP126946:c971922-971380 [Escherichia coli O78:H51]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT283269 WP_001297137.1 NZ_CP126946:c972217-971906 [Escherichia coli O78:H51]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References