Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 261026..261621 Replicon chromosome
Accession NZ_CP126946
Organism Escherichia coli O78:H51 strain APEC E18005

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QQA24_RS01295 Protein ID WP_000239579.1
Coordinates 261271..261621 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QQA24_RS01290 Protein ID WP_001223208.1
Coordinates 261026..261277 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA24_RS01280 (256690) 256690..260469 + 3780 WP_000060901.1 autotransporter assembly complex protein TamB -
QQA24_RS01285 (260472) 260472..260813 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QQA24_RS01290 (261026) 261026..261277 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QQA24_RS01295 (261271) 261271..261621 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QQA24_RS01300 (261701) 261701..262231 - 531 WP_000055072.1 inorganic diphosphatase -
QQA24_RS01305 (262541) 262541..263497 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QQA24_RS01310 (263807) 263807..265309 + 1503 WP_000205793.1 sugar ABC transporter ATP-binding protein -
QQA24_RS01315 (265323) 265323..266345 + 1023 WP_001339490.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T283267 WP_000239579.1 NZ_CP126946:261271-261621 [Escherichia coli O78:H51]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT283267 WP_001223208.1 NZ_CP126946:261026-261277 [Escherichia coli O78:H51]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References