Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 92992..93489 Replicon chromosome
Accession NZ_CP126946
Organism Escherichia coli O78:H51 strain APEC E18005

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QQA24_RS00460 Protein ID WP_001173343.1
Coordinates 93316..93489 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QQA24_RS00455 Protein ID WP_000398619.1
Coordinates 92992..93288 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA24_RS00435 (89723) 89723..90442 - 720 WP_000611288.1 two-component system response regulator DcuR -
QQA24_RS00440 (90439) 90439..92070 - 1632 WP_001216461.1 sensor histidine kinase -
QQA24_RS00445 (92251) 92251..92481 + 231 WP_000371698.1 4Fe-4S mono-cluster protein YjdI -
QQA24_RS00450 (92493) 92493..92765 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
QQA24_RS00455 (92992) 92992..93288 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QQA24_RS00460 (93316) 93316..93489 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QQA24_RS00465 (93608) 93608..95125 - 1518 WP_001295074.1 lysine--tRNA ligase -
QQA24_RS00470 (95362) 95362..96819 - 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T283265 WP_001173343.1 NZ_CP126946:93316-93489 [Escherichia coli O78:H51]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT283265 WP_000398619.1 NZ_CP126946:92992-93288 [Escherichia coli O78:H51]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References